Methylation of Quinazolin-4-One with "Soft" and "Hard" Methylating Agents

Authors

  • F. E. Saitkulov Tashkent State University, Universitetity Street
  • N. Sh. Ropijonova Tashkent State University, Universitetity Street
  • B. J. Elmuradov Institute of Plant Chemistry of the Academy of Sciences of Uzbekistan

Keywords:

methylation, qinazolin-4-оn, soft, hard, alkylation agents, methyl iodide, dimethylsulfate, methyltosylate, proton polar ethanol, aproton аpolar, aproton dipolar solvents, dimethyl formamide, dimethyl sulfoxide

Abstract

For the first time methylation of qinazolin-4-оne by “soft” and “hard” alkylation agents (methyl iodide, dimethylsulfate, methyltosylate) in proton polar ethanol, aproton аpolar, aproton dipolar solvents (dioxane-1,4, acetonitrile, dimethyl formamide, dimethyl sulfoxide) was studied. It was shown, that the reaction goes in two directions on atom nitrogen N-3 and oxygen O-4. It is find, that N-3/O-4 relation depends on nature of methylation agents, solvent and temperature.

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Published

2022-01-20

How to Cite

Saitkulov, F. E. ., Ropijonova, N. S. ., & Elmuradov, B. J. . (2022). Methylation of Quinazolin-4-One with "Soft" and "Hard" Methylating Agents. International Journal of Development and Public Policy, 1(8), 97–101. Retrieved from https://openaccessjournals.eu/index.php/ijdpp/article/view/929

Issue

Vol. 1 No. 8 (2022): January 2022

Section

Articles