Peculiarities of the Action of Fosmetrine on Bioenergetic Processes in Mitochondria and Lipid Metabolism in RAT Liver
Keywords:
Phosphomethrin, pesticides, mitochondria, liver, total lipids, phospholipidsAbstract
Administration of 440 g/l (0.2 ml per 100 g body weight intraperitoneally) to male rats leads to a significant decrease in respiration rate of liver mitochondria in the 3rd metabolic state and to some activation in the 2nd metabolic state after 2 h of poisoning with their further partial normalization by 20 h. A decrease in the efficiency of oxidative phosphorylation of ADP in mitochondria correlates with the dynamics of phospholipid and β-lipoprotein content in the liver. Disturbances of bioenergetic processes in mitochondria precede the accumulation of total lipids in the liver. The decrease of cholesterol content in liver tissue is the result of disruption of its synthesis in the membranes of endoplasmic reticulum.